📝 Preprints

BRIDGE: A Cross-organ Foundation Model for Bridging Histology Imaging and Spatial Transcriptomics
Zhuo Liang$^{*}$, Weiqin Zhao$^{*}$, Fuying Wang, Yuanhua Huang, Lequan Yu.

Cell systems Under Review   

Present a multi-organ foundation model pre-trained on over 600,000 image-gene paired profiles from 13 organs with various sequencing techniques, to connect cross-organ morphology and genomics for cost-effective histology analysis. Without fine-tuning, BRIDGE enables accurate gene inference for over 80 biomarker genes across 10 human organs, enhances survival analysis for six different types of cancer by using histopathology images from TCGA cohorts and shows potential as a cost-efficient alternative to bulk RNA sequencing.